Inhaler technique blind spot

We would like to thank D. Stanescu for giving us the opportunity to clarify the definition of airflow obstruction recently given in the interpretative strategies document from the American Thoracic Society/European Respiratory Society (ERS) Task Force [1]. The document states that in most cases a ratio of forced expiratory volume in one second (FEV1) to vital capacity (VC) below the lower limits of normality is the parameter that best and most frequently embodies the concept of airflow obstruction with few exceptions. However, in some cases, a low FEV1 with a normal FEV1/VC may also be consistent with an obstructive pattern if total lung capacity is normal. This pattern has been observed after exposing the airways to a constrictor agent [2, 3] or in natural respiratory diseases [4], reproduced in healthy subjects [5, 6], and has already been interpreted as consistent with airway narrowing in the 1993 ERS guidelines on lung function testing [7]. The fact that this may be caused by a patchy collapse of the small airways on early expiration or expiratory flow limitation that, in turn, would cause an increase in residual volume was suggested by OLIVE and HYATT [2] in 1972 and then by other investigators in the years that followed [3, 5, 6]. However, this hypothesis still needs confirmation, especially after the demonstration that even the large airways may close with induced bronchoconstriction [8], thus suggesting that the small airways are not the only ones that may contribute towards the generation of air trapping and an increase in residual volume.